How do NDMA levels in food compare to those in ARB drugs?

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NDMA Levels in Food Significantly Exceed Regulatory Limits for ARB Drugs

NDMA levels found in various food products, such as meat, milk, and fish, far surpass the maximum daily intake limit set by the US Food and Drug Administration (FDA) for ARB drugs. While the FDA mandates a maximum of 96 nanograms per day (ng/day) for NDMA in these medications, food items present considerably higher concentrations.
NDMA in Food Products

NDMA concentrations in food can reach substantial levels, exceeding the pharmaceutical regulatory threshold. For instance, meat products have been reported to contain up to 370 nanograms per kilogram (ng/kg) of NDMA. Similarly, milk can have up to 700 ng/kg, and fish can contain as much as 820 ng/kg of this contaminant. These figures indicate that consumption of these common food items can lead to a higher daily intake of NDMA than the FDA's prescribed limit for ARB medications.
NDMA in Beverages and Tobacco

Beyond solid foods, beverages and tobacco also contribute to NDMA exposure. Canadian beer has been found to contain up to 590 nanograms per litre (ng/L) of NDMA, with imported beer to Canada showing even higher levels, reaching up to 3,200 ng/L. In the context of smoking, NDMA levels can reach up to 76 ng per cigarette. Environmental tobacco smoke is also a source, potentially exposing an adult to up to 50 ng/kg body weight per day of NDMA.
Comparison with Pharmaceutical Limits

The FDA's stipulated maximum daily intake of NDMA from ARB drugs is 96 ng/day. This limit is significantly lower than the amounts of NDMA found in many food and beverage products. For example, consuming a portion of fish with 820 ng/kg of NDMA could rapidly exceed the daily limit intended for a critical medication. The widespread presence of NDMA in everyday consumables suggests a broader environmental contamination issue that extends beyond pharmaceutical products.

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How do NDMA levels in food compare to those in ARB drugs?

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