How does the D-MNA patch treat squamous cell carcinoma in horses?

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The D-MNA Patch Delivers Doxorubicin Directly to Tumors Via Microneedles

The Doxorubicin-containing microneedle array (D-MNA) patch treats external squamous cell carcinoma (SCC) in horses by delivering the chemotherapy drug doxorubicin directly into the tumor. This method involves a patent-protected, dissolvable transdermal patch designed with cellulose-based microneedle arrays. Once applied to the skin, these microneedles penetrate the stratum corneum, create temporary microchannels, and then enter the tumor itself. Within the tumor, the microneedles dissolve, releasing doxorubicin to target and eradicate the cancer cells.
Penetration and Dissolution Mechanism

The D-MNA patch utilizes its specialized microneedle structure to bypass the outer skin layer. The sharp tips of the microneedles are designed to penetrate the stratum corneum, the outermost layer of the skin. This penetration creates a pathway, allowing the microneedles to reach the underlying tumor tissue. Once in contact with the tumor, the cellulose-based microneedle arrays are engineered to dissolve, initiating the controlled release of the loaded doxorubicin directly at the site of the cancer.
Targeted Drug Delivery

This transdermal delivery system is intended to provide a localized and targeted approach to treating SCC. By releasing doxorubicin directly within the tumor, the D-MNA aims to maximize the drug's efficacy against cancer cells while potentially minimizing systemic exposure. The tip-loading of doxorubicin onto the microneedles ensures that the active chemotherapeutic agent is precisely delivered to the cancerous tissue upon dissolution of the microneedles.
Potential for Non-Invasive Treatment

The development of the D-MNA patch represents an effort to create a non-invasive treatment option for equine SCC. Traditional treatments for SCC in horses can include surgery, cryotherapy, or topical and oral medications. The D-MNA patch offers an alternative that aims to deliver chemotherapy directly to the tumor without the need for extensive surgical intervention, potentially improving the treatment experience for the animal.

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How does the D-MNA patch treat squamous cell carcinoma in horses?

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