Which 10 cancer types does SPOT-MAS 10 aim to detect?

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SPOT-MAS 10 Aims to Detect Ten Specific Cancer Types

The SPOT-MAS 10 multi-cancer screening test is designed to identify a total of ten distinct types of cancer. This includes five common cancers and five aggressive, less common cancers that often lack established screening methods. The test analyzes circulating cell-free DNA methylation and fragmentomic signatures to detect a cancer-associated signal.
Five Common Cancers Targeted

The test aims to detect prevalent cancer types, specifically breast, lung, liver, colorectal, and gastric cancers. These are cancers that represent a significant portion of the global cancer burden and for which early detection is crucial for improved patient outcomes.
Five Aggressive, Less Common Cancers Targeted

In addition to common cancers, SPOT-MAS 10 also targets five aggressive and less frequently screened cancers. These include ovarian, pancreatic, esophageal, endometrial, and head & neck cancers. The inclusion of these types addresses a critical unmet need in cancer diagnostics, offering potential for earlier detection in cases where standard screening protocols are not yet widely available or effective.
Method of Detection

SPOT-MAS 10 operates as a qualitative in vitro diagnostic test performed on plasma derived from a single venous whole blood specimen. It employs a machine-learning-based algorithm to analyze circulating cell-free DNA methylation and fragmentomic signatures. This comprehensive analysis aims to identify a cancer-associated signal, distinguishing it from non-cancerous conditions.
Intended Use and Target Population

The test is intended for use as an adjunctive screening tool in asymptomatic adults aged 40 years and older. It serves to assist in the detection of cancers within the scope of its assay. This designation as an adjunctive screening test means it is meant to be used in conjunction with other medical evaluations and diagnostic procedures, not as a standalone diagnostic.

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Which 10 cancer types does SPOT-MAS 10 aim to detect?

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