Which vaccine combination showed the highest neutralising antibody levels?

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CanSino Biologics' Vaccine as a Booster Yields Superior Antibody Response Compared to Sinovac Alone

A study examining heterologous vaccine boosting in China has demonstrated that a CanSino Biologics' adenovirus vector vaccine booster, when administered after one or two doses of Sinovac Biotech's inactivated vaccine, elicits a significantly stronger neutralising antibody response than using the Sinovac vaccine as a booster. This research, among the initial analyses in China to investigate the mixing of different COVID-19 vaccines, provides valuable insights as the country considers booster shots for specific demographics due to concerns about diminishing vaccine efficacy over time.
CanSinoBIO Booster After Two Sinovac Doses Significantly Elevates Antibodies

Participants who received a CanSino Biologics booster dose between three to six months after completing a two-dose Sinovac regimen experienced an average 78-fold increase in neutralising antibody levels within two weeks. This contrasts sharply with individuals who received a Sinovac booster, which resulted in a more modest 15.2-fold increase in neutralising antibodies. These findings were detailed in a paper published prior to peer review by researchers from local disease control authorities and CanSino Biologics, among other Chinese institutions.
Single Sinovac Dose Followed by CanSinoBIO Booster Also Shows Strong Response

When a single dose of the Sinovac vaccine was followed by a CanSino Biologics booster at intervals of one to two months, neutralising antibody levels saw a substantial 25.7-fold increase. For comparative purposes, individuals who received two doses of the Sinovac vaccine without a heterologous booster showed a 6.2-fold increase in antibody levels.
Study Sample and Limitations

The research analysed data from approximately 300 healthy adults aged between 18 and 59 years old. It is important to note that the study did not evaluate the boosters' efficacy in preventing COVID-19 infection and did not specifically test the neutralising antibodies against the more transmissible Delta variant of the virus, as stated in the paper.

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Which vaccine combination showed the highest neutralising antibody levels?

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